Here is pROC 1.4.1. It introduces a single feature, but a significant one: unpaired Venkatraman's test¹. Now you can write:

library(pROC)
set.seed(1)
response1 <- round(runif(1000, 0, 1))
response2 <- round(runif(1000, 0, 1))
predictor1 <- response1 + rnorm(1000)
predictor2 <- response2 + rlnorm(1000)

roc1 <- roc(response1, predictor1, plot=TRUE)
roc2 <- roc(response2, predictor2, plot=TRUE, add=TRUE)

are.paired(roc1, roc2)

roc.test(roc1, roc2, method="delong")
roc.test(roc1, roc2, method="venkatraman", boot.n=200)

Here is the full change log:

• Venkatraman's test for unpaired ROC curves.

As usual, you can find the new version on ExPASy and on the CRAN. To update, type update.packages() or install.packages("pROC") if you want to update pROC only.

• 1. E. S. Venkatraman (2000) “A Permutation Test to Compare Receiver Operating Characteristic Curves”. Biometrics 56, 1134–1138. DOI: 10.1111/j.0006-341X.2000.01134.x.